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Cardinals vs 49ers odds, spread, line: Mexico City Monday Night Football picks, top NFL models predictions

Cardinals vs 49ers odds, spread, line: Mexico City Monday Night Football picks, top NFL models predictions

Estadio Azteca will host the NFL’s fourth ever game in Mexico on Monday night. The Arizona Cardinals and San Francisco 49ers will meet in the rematch of the first NFL the game was played outside the United States when the Cardinals beat the 49ers in Mexico City in 2005. Arizona won both games against San Francisco in the 2021 season, but the Cardinals are just 4-6 heading into the 2022 campaign. The 49ers are 5-4 overall after back-to-back wins. Cardinals quarterback Kyler Murray inactive with a hamstring injury.

Kickoff is scheduled for 8:15 p.m. ET. San Francisco is a 10-point favorite in the latest Cardinals vs. 49ers odds from Caesars Sportsbook, with an Over/Under total points score of 43. Before locking in any 49ers vs. Cardinals picks ” or NFL Week 11 bets, you have to check out NFL predictions from SportsLine’s projection model.

The model, which simulates every NFL play 10,000 times, costs well over $7,000 for the highest-rated $100 players NFL draft picks since its inception. The model enters Week 7 of the 2022 NFL season with an incredible 153-108 record for the highest-rated NFL pick dating back to the 2017 season.

The model also finished in the top 10 on NFLPickWatch four times in the past six years in direct NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who followed that goes above.

Now, the model broke down Monday night’s 49ers vs. Cardinals matchup. You can head to SportsLine to see the picks. Here are some betting lines and trends for the Cardinals vs. 49ers:

  • Cardinals vs. 49ers: San Francisco -10
  • Cardinals vs. 49ers Over/Under: 43 points
  • Cardinals vs. 49ers money line: San Francisco -480, Arizona +360
  • SF: Niners are 48-47-1 ATS (50.5%) under coach Kyle Shanahan (since 2017)
  • AZ: The Cardinals are 31-27-2 ATS (53.4%) under Kliff Kingsbury (since 2019).

Why the 49ers can cover

The 49ers are 3-0 across divisional games this season and have the best defense in the NFL in terms of total yardage. They allow 281 yards per game and 18 points per contest (fourth most). They are also chasing the quarterback, posting 29 sacks, fifth most in the NFL. Nick Bosa ranks second with 9.5 and leads the NFL with 24 quarterback hits. Arizona’s defenders were sacked 27 times, so the pressure will continue all night.

Arizona’s offense ranks 13th in scoring (23 points) and 19th in rushing yards (334), while giving up nearly 358 yards (23rd) and 26 points (30th). Running back Christian McCaffrey has 226 yards and three TDs in last two games, and the quarterback Jimmy Garoppolo has many elite options in the passing game. Maybe Samuel (total 576 yards), Brandon Ayuk (567 receptions) and George Kittle (29 catches) must find the seams in a Cardinals defense that is allowing 247 passing yards per game (23rd). See which team to choose here.

Why the Cardinals can cover

Kyler Murray is out with a hamstring injury. However, the Cardinals have a stellar wide receiver to make life easier as a backup Colt McCoy. DeAndre Hopkins is a five-time Pro Bowler and three-time All-Pro who ranks in the top three among active players in career receptions, receiving yards and receiving touchdowns. Hopkins is averaging nine catches per game this season and has 396 receiving yards since his debut in Week 7, third most among all players over that span.

Arizona is scoring an above average 23.0 points per game, while the Cardinals are better than average in first downs (206) and red zone efficiency (60.0%). The Cardinals are also in the top five in turnovers, committing just nine turnovers, while San Francisco has just 10 defensive turnovers through nine games. See which team to choose here.

How to pick Cardinals vs. 49ers

The model analyzed Monday night’s game between the Cardinals and the 49ers from every angle. This is skewed towards the total, with the model suggesting that damages can disrupt offences. The model also strongly opposes the spread, saying that one side gets paid more than 50 percent of the time. You can only get the pick at SportsLine.

So who will win 49ers vs. Cardinals on Monday Night Football in Mexico City? And which side of the spread gets hit in more than 50 percent of the simulations? Visit SportsLine now to find out whose 49ers vs. Cardinals side you should be on, everything from the 153-108 shooting model to her top NFL rankings.





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