Patriots vs. Cardinals odds, spreads, line: Monday Night Football picks, NFL predictions from the advanced model

The New England Patriots will try to get back on track when they struggle with Arizona Cardinals in a key match on Monday night. Patriots (6-6) looking to reach NFL playoff berth for the second straight season, have made the playoffs 18 times in the last 21 years, winning six Super Bowl championships during this period. The Cardinals (4-8), meanwhile, will see their postseason hopes nearly dashed by another loss. Arizona is trying to make the playoffs for the second year in a row and just the seventh time since the franchise moved to Phoenix in 1988. Jacob Meyers (concussion) and Cardinals wide receiver Rondale Moore (groin) both inactive.

Kickoff at State Farm Stadium in Glendale, Arizona is scheduled for 8:15 p.m. ET. New England is a 2.5-point favorite in the latest Patriots vs. Cardinals odds from Caesars Sportsbook, while the over/under for total points is 44. Before locking in any picks on the Cardinals against the Patriots” or NFL betting, you should check out NFL predictions from SportsLine’s projection model.

The model, which simulates every NFL play 10,000 times, costs more than $7,000 for the highest-rated $100 players NFL draft picks since its inception. The model enters Week 14 of the 2022 NFL season with an incredible 156-112 top-ranked record. NFL draft picks which dates back to the 2017 season.

The model has also ranked in the top 10 on NFLPickWatch four of the last six years in direct NFL picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who followed that goes above.

Now the model is broken Patriots vs. Cardinals at MNF. You can head to SportsLine to see the picks. Here NFL lines and trends for Cardinals vs. Patriots:

• Patriots vs. Cardinals: New England -2.5
• Patriots vs. Cardinals over/under: 44 points
• Patriots vs. Cardinals money line: Patriots -135, Cardinals +115
• NE: Patriots are 12-2 against the spread in their last 14 games following a double-digit loss at home
• ARI: Cardinals are 5-2 ATS in their last seven games following a straight up loss
• Patriots vs. Cardinals: Watch the picks on SportsLine

Why the patriots can cover

New England’s defense has been strong all season. Midfielder Matthew Judon suffered his first setback of the season last week. For the year, he is among the team leaders with 46 tackles, including 26 single tackles. He was sacked in his only career game against Arizona as a member Baltimore Ravens on September 15, 2019, and has had a lot of success on Monday Night Football, registering 3.5 sacks in his last two games. Judon is tied for second in the NFL with 13 sacks this season.

linebacker Josh Uche had seven tackles, two sacks and first career forced fumble in Week 13. He is looking for his third straight game with a sack. Uche has a season-high 19 tackles, including 17 solo, with seven sacks for 27 yards and five tackles for loss. He had six tackles, including five solo, with three sacks in a Nov. 6 win over Indianapolis. See which team to choose here.

Why the Cardinals can cover

Wide receiver Deandre Hopkins had 87 receiving yards and his third touchdown of the season in a Week 12 loss to the team Los Angeles Chargers. He has 85-plus yards receiving in five of six games in 2022. He needs one catch for his ninth career 50-catch season. Since 2013, he leads the NFL in receiving yards (838) and ranks second in receptions (11,155). He will look for his fifth straight game against New England with five or more catches and has 50 or more receiving yards in 11 of his 12 Monday Night Football games.

Wide receiver Marquise Brown will go for seventh straight game with five or more catches. He has five touchdowns in five career MNF games and will look for his fourth straight game on Monday Night Football with a touchdown catch. For the season, Brown has 49 receptions for 531 yards (10.8 average) and three touchdowns. He has eight explosive plays of 20 or more yards, including a long of 26 yards, and has converted 26 first downs. See which team to choose here.

How to make a Cardinals vs. Patriots pick

The model analyzed Monday night’s Patriots vs. Cardinals matchup from every angle. It relies on the total, with the model highlighting 42 total points. It also says that one side of the spread gets paid in more than 50% of the simulation. See who it is at SportsLine.

So who will win Cardinals vs. Patriots on Monday Night Football? And which side of the spread wins more than 50% of the time? Visit SportsLine now to find out which side of the Cardinals vs. Patriots you should be on everywhere from the 156-112 shooting model to her top NFL rankings.and find out.